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NCLEX Pharmacology Review

NCLEX Review: Neurological Medications 

MAOI  (Monoamine oxidase inhibitors)

Important Medications in the NCLEX includes

  • Parnate (tranylcypromine sulfate)
  • Nardil (phenelzine sulfate)
Side Effects of MAOI

MAOI Side Effects

  • Dizziness
  • Dry mouth
  • Diarrhea
  • Weight gain

Remember: Do not take MAOI’s with TCAs and SSRIs

NCLEX Review: Remember to limit foods that contain high levels of tyramine, such as cheese, pickled foods, beer and wine

MAOIs or Monoamine oxidase inhibitors act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability. Which gives off positive effects on depression and anxiety. so again basically MAOI’s helps balance certain brain chemicals called neurotransmitters and it does this by reducing the amount of monoamine oxidase which the substance that breaks down the neurotransmitters, hence there would be more neurotransmitter in the brain which helps decrease the symptoms of depression.

Now the 2 important MAOI’s drugs that you might encounter in your NCLEX exam includes:

  1. Parnate  (tranylcypromine sulfate)
  2. Nardil  (phenelzine sulfate)

As we learn from our Psych class back in nursing school, We as nurses don’t usually offer MAOI because of the lethal dietary and drug interactions (and this is the most important thing that we have to know for the NCLEX in reagards with MAOI and this is also a big reason why MAOI is usually used as last line of treatment and is used only when other classes of antidepressant drugs (for example SSRI and TCA’s) have failed.

NCLEX Review Neurological Pharmacology

We need to know for the NCLEX that our patient needs to limit foods that contain high levels of tyramine, such as cheese, pickled foods, beer and wine.  And here is why…. well because Tyramine is an amino acid that helps regulate blood pressure. So basically if we combine tyramine with MAOIs the interaction cause dangerously severe high blood pressure it can trigger a hypertensive crisis… and we don’t want that on our patient.

So again, the biggest tip we can take away from this video is to remember that when giving MAOI’s… avoid food with high levels of tyramine…. so no cheese, pickles and beer or wine.

Study Hard and Good Luck  : )



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