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  • – Promotes the transport of glucose into the cells so it can be used as energy source.
  • – Promotes conversion of glucose to glycogenfor storage in the liver

Treatment for:

  • Type 1 diabetes,
  • Type 2 diabetes that is uncontrolled with diet, exercise and
    oral medications
  • hypergylcemia caused by TPN
  • treat hyperkalemia (causes K to move from blood
    into cells).

Side Effects:




  • Hypoglycemia
  • Hypersensitivity to pork for pork insulin

Short Acting Insulin

Regular: Regular Inletin II, Humulin R,
Novolin R  (the only IV insulin).

Rapid acting.
Onset ½-1 hour, peak 2-3 hr, duration 5-7hr.

Intermediate Acting Insulin

  • Isophane insulin suspension – NPH, NPH
  • Iletin II, Humulin N, Novolin N.
  • Insulin zinc suspension – Lente, Ilentin II,
  • Lente L, , Humulin L, Novolin L.

Onset 1-11/2 hr, peak 8-12 hr, duration 18-24

Long Acting Insulin

  • Humulin U,
  • Ultralente

Route – SC
Onset 4-8 hr, peak 10-30 hr, duration > 36 hr.
Rarely used.

Mixed Insulin

NPH 70%, Regular 30% – Humulin 70/30,
Novolin 70/30.
NPH 50%, Regular 50% – Humulin 50/50
Stable mixtures with onset, peak and duration
of action the same as the N and R

Route – SC
Frequently used when patients have trouble
mixing N and R insulin accurately



A decrease in the amount of serum glucose level


– confusion
– headaches
– tachycardia
– hypotension

Liver Disease


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