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Parkinsons Disease

– degenerative disease caused by the decrease and lack of dopamine in the brain.

*There is a decrease in dopamine (and increased in acetylcholine)

 

Diagnostics:

  • CAT Scan
  • MRI
  • CT Scan

Assessment:

  • TREMORS IN HANDS AND FINGERS (PILL ROLLING)
  • AKINESIA
  • BRADYKINESIA
  • BLANK FACIAL EXPRESSION
  • SHUFFLING STEPS AND GAIT
  • RESTLESSNESS

TREATMENTS:

Antiparkinsonian Agents

Cholinergic Medications  (Anticholinesterase)

– they help relieve the muscle weakness.

– blocks acetycholine breakdown. 

  • Pyridostigmine (Mestinon)
  • Neostigmine (Prostigmine)
  • Edrophonium Chloride (Tensilon)
  • – Used for Myasthenia Gravis

Dopaminergics

Levodopa

  *Levodopa is contraindicated w/ pts. with angle-closure glaucoma.

Carbidopa/ Levodopa

side effects:

  • Dyskinesia
  • Nausea
  • Confusion
  • Dizziness
  • Depression
  • Urinary tract infection
  • Headache
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