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Drugs that affects the GI Physiology: (Affects the gastric acid secretion)

  • Antacids
  1. – protects and becomes a barrier against the strong acidic hydrochloric acid of the stomach, through buffer system.
  2. – Neutralizes the acid in the stomach.
  3. – Such as Maalox, Magnesium Hydroxide, Mylanta, Sodium Bicarbonate, Aluminum salts.
  4. – Side effects can include constipation, diarrhea and belching
  5. – Given after meals
  • Proton Pump Inhibitor
  1. –  Blocks the “Hydrogen Ion” mechanism in the “parietal cells” of the stomach, causing (total) blockage of HCL excretion.
  2. – Medications includes: Prevacid, Prilosex, Nexium, Protonix, Aciphex, Sucralfate (Carafete).
  3. Used for maintenance of GERD and Zollinger-Ellison syndrome.
  • H2 Receptor (Blocker/Antagonists)
  1. – In the stomach, it can decrease and reduce the HCL secretion
  2. – Medications includes: Ranitidine (Zantac), Cimetedine (Tagament), Pepsin and Axid.
  3. – Targets the “parietal cells” and blocks the receptors, disrupting the production of acid.
  4. – Take at least an hour or two before taking atacids.

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